Symbol
Name
ID

Spi1
Spi-1 proto-oncogene
MGI:98282

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Decreased circulating IgA level	Decreased circulating IgG level	Decreased circulating total IgM	Agammaglobulinemia	Transient neutropenia	Absent circulating B cells
Disease(s) Associated with SPI1
agammaglobulinemia 10

Mouse Phenotypes

hematopoietic system phenotype

abnormal granulocyte differentiation

abnormal neutrophil differentiation

abnormal macrophage differentiation

increased hematopoietic stem cell proliferation

small thymus

decreased thymocyte number

enlarged spleen

increased spleen weight

spleen hyperplasia

abnormal blood cell morphology/development

abnormal definitive hematopoiesis

abnormal common myeloid progenitor cell morphology

absent common myeloid progenitor cells

abnormal erythropoiesis

abnormal leukopoiesis

abnormal B cell differentiation

decreased pro-B cell number

arrested B cell differentiation

abnormal T cell differentiation

abnormal double-negative T cell morphology

decreased double-negative T cell number

increased double-negative T cell number

decreased double-positive T cell number

abnormal myelopoiesis

failure of myelopoiesis

impaired myelopoiesis

extramedullary hematopoiesis

anemia

abnormal bone marrow cell morphology/development

increased bone marrow cell number

abnormal proerythroblast morphology

abnormal erythrocyte cell number

abnormal fetal derived definitive erythrocyte cell number

decreased erythrocyte cell number

absent erythrocytes

decreased hematocrit

increased mean corpuscular volume

abnormal granulocyte morphology

decreased neutrophil cell number

increased neutrophil cell number

decreased granulocyte number

increased granulocyte number

abnormal B cell number

decreased mature B cell number

absent mature B cells

decreased B-1a cell number

increased B-1 B cell number

increased B-1b cell number

decreased B cell number

absent B cells

decreased pre-B cell number

abnormal T cell subpopulation ratio

abnormal T cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased T cell number

increased T cell number

increased lymphocyte cell number

decreased macrophage cell number

decreased hematopoietic stem cell number

increased hematopoietic stem cell number

abnormal microglial cell morphology

abnormal monocyte morphology

abnormal spleen morphology

decreased spleen red pulp amount

abnormal hematopoietic system physiology

increased IgM level

abnormal hematopoietic stem cell physiology

Availability

Mouse Genotype

Spi1^tm1.1Dgt/Spi1^tm1.1Dgt

Spi1^tm1.1Nutt/Spi1^tm1.1Nutt

Spi1^tm1.1Rpd/Spi1^tm1.1Rpd

Spi1^tm1.3Dgt/Spi1^tm1.3Dgt

Spi1^tm1.3Nutt/Spi1^tm1.3Nutt

Spi1^tm1Kast/Spi1^tm1Kast

Spi1^tm1Ram/Spi1^tm1Ram

Spi1^tm1Rpd/Spi1^tm1Rpd

Spi1^tm1Sing/Spi1^tm1Sing

Spi1^tm2.1Dgt/Spi1^tm2.1Dgt

Spi1^tm2Dgt/Spi1^tm2Dgt

Spi1^tm3Dgt/Spi1^tm3Dgt

Spi1^tm4.1Dgt/Spi1^tm4.1Dgt

Spi1^tm1Kast/Spi1⁺

Spi1^{tm2b(EUCOMM)Wtsi}/Spi1⁺

Spi1^tm1.2Nutt/Spi1^tm1.2Nutt
Tg(Mx1-cre)1Cgn/0 (conditional)

Spi1^tm2Dgt/Spi1^tm2Dgt
Tg(Mx1-cre)1Cgn/0 (conditional)

Cd19^tm1(cre)Cgn/Cd19⁺
Spi1^tm2Dgt/Spi1^tm2Dgt (conditional)

Spi1^tm2.1Dgt/Spi1^tm2Dgt
Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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